| 2. Round | 13/09/1980 | Hércules CF | - | Sporting Gijón | 1:1 | ||||
| 3. Round | 20/09/1980 | Valencia CF | - | Hércules CF | 0:2 | ||||
| 4. Round | 27/09/1980 | Hércules CF | - | CA Osasuna | 0:0 | ||||
| 9. Round | 01/11/1980 | Hércules CF | - | FC Barcelona | 0:1 | ||||
| 12. Round | 22/11/1980 | Real Madrid | - | Hércules CF | 3:0 | ||||
| 15. Round | 13/12/1980 | Hércules CF | - | Athletic Club | 1:2 | ||||
| 17. Round | 27/12/1980 | Hércules CF | - | Real Murcia | 1:0 | ||||
| 18. Round | 03/01/1981 | Hércules CF | - | Espanyol Barcelona | 2:0 | ||||
| 19. Round | 10/01/1981 | Sporting Gijón | - | Hércules CF | 3:1 | ||||
| 20. Round | 17/01/1981 | Hércules CF | - | Valencia CF | 1:1 |  |
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| 21. Round | 24/01/1981 | CA Osasuna | - | Hércules CF | 1:2 | |
Spain