| 15. Round | 23/01/2022 | Tours FC [Youth B] | - | Blois Foot 41 [Youth B] | 2:0 | ||||
| 16. Round | 06/02/2022 | Paris Saint-Germain [Youth B] | - | Tours FC [Youth B] | 9:1 | ||||
| 17. Round | 12/02/2022 | Tours FC [Youth B] | - | Le Mans FC [Youth B] | 1:4 |  |
|||
| 18. Round | 06/03/2022 | SM Caen [Youth B] | - | Tours FC [Youth B] | 3:2 | |
|||
| 19. Round | 13/03/2022 | Tours FC [Youth B] | - | AS Vitré [Youth B] | 2:1 | ||||
| 20. Round | 20/03/2022 | FC Rouen 1899 [Youth B] | - | Tours FC [Youth B] | 2:1 | |
|||
| 21. Round | 27/03/2022 | Tours FC [Youth B] | - | Montrouge FC [Youth B] | 1:0 | |
|||
| 22. Round | 03/04/2022 | Paris FC [Youth B] | - | Tours FC [Youth B] | 4:0 | ||||
| 23. Round | 09/04/2022 | Tours FC [Youth B] | - | US Orléans [Youth B] | 1:1 | ||||
| 24. Round | 14/04/2022 | Tours FC [Youth B] | - | US Avranches [Youth B] | 2:3 | ||||
| 25. Round | 01/05/2022 | CS Brétigny [Youth B] | - | Tours FC [Youth B] | 4:3 | |
|||
| 26. Round | 15/05/2022 | Tours FC [Youth B] | - | FC Mantois [Youth B] | 2:4 |
France