| 19. Round | 11/01/2025 | SD Ponferradina | - | Sestao River | 1:2 | ||||
| 20. Round | 17/01/2025 | Sestao River | - | Real Unión | 0:1 | ||||
| 21. Round | 25/01/2025 | Athletic Club B | - | Sestao River | 2:0 | ||||
| 22. Round | 01/02/2025 | Sestao River | - | Cultural Leonesa | 1:1 | ||||
| 23. Round | 08/02/2025 | Sestao River | - | Zamora CF | 1:1 | ||||
| 24. Round | 16/02/2025 | CD Lugo | - | Sestao River | 2:1 | ||||
| 27. Round | 07/03/2025 | Sestao River | - | Real Sociedad B | 0:0 | ||||
| 28. Round | 14/03/2025 | RC Celta B | - | Sestao River | 1:1 | ||||
| 29. Round | 22/03/2025 | Sestao River | - | SD Tarazona | 0:2 | ||||
| 30. Round | 30/03/2025 | CA Osasuna B | - | Sestao River | 1:5 | ||||
| 31. Round | 05/04/2025 | Sestao River | - | Gimnàstic de Tarragona | 3:2 | ||||
| 32. Round | 13/04/2025 | FC Barcelona B | - | Sestao River | 2:0 | ||||
| 33. Round | 19/04/2025 | Barakaldo CF | - | Sestao River | 2:3 |  |
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| 34. Round | 27/04/2025 | Sestao River | - | Ourense CF | 2:2 | ||||
| 35. Round | 04/05/2025 | Unionistas CF | - | Sestao River | 0:0 | ||||
| 36. Round | 11/05/2025 | Sestao River | - | Gimnástica Segoviana | 1:2 | ||||
| 37. Round | 17/05/2025 | FC Andorra | - | Sestao River | 1:2 | ||||
| 38. Round | 24/05/2025 | Sestao River | - | SD Ponferradina | 0:2 |
Spain