| 1. Round | 08/01/2022 | Mazatlán FC [Women] | - | Cruz Azul [Women] | 1:2 | ||||
| 4. Round | 27/01/2022 | Cruz Azul [Women] | - | FC Juárez [Women] | 1:0 | ||||
| 5. Round | 01/02/2022 | Deportivo Guadalajara [Women] | - | Cruz Azul [Women] | 1:0 | ||||
| 6. Round | 05/02/2022 | Cruz Azul [Women] | - | CF América [Women] | 1:3 | ||||
| 7. Round | 12/02/2022 | Pumas UNAM [Women] | - | Cruz Azul [Women] | 1:1 | ||||
| 8. Round | 26/02/2022 | Cruz Azul [Women] | - | Club Tijuana [Women] | 2:2 | ||||
| 10. Round | 12/03/2022 | Cruz Azul [Women] | - | Santos Laguna [Women] | 2:3 | ||||
| 11. Round | 18/03/2022 | UANL Tigres [Women] | - | Cruz Azul [Women] | 4:0 | ||||
| 12. Round | 21/03/2022 | Cruz Azul [Women] | - | CF Pachuca [Women] | 0:2 | ||||
| 9. Round | 11/04/2022 | Deportivo Toluca [Women] | - | Cruz Azul [Women] | 3:1 | ||||
| 16. Round | 22/04/2022 | Club Necaxa [Women] | - | Cruz Azul [Women] | 1:2 |
Mexico