| 1. Round | 23/07/1980 | Lille OSC | - | RC Strasbourg | 3:0 | ||||
| 2. Round | 28/07/1980 | Paris Saint-Germain | - | RC Strasbourg | 1:0 | ||||
| 9. Round | 08/09/1980 | RC Strasbourg | - | FC Sochaux | 2:0 | ||||
| 10. Round | 11/09/1980 | RC Lens | - | RC Strasbourg | 1:2 | ||||
| 11. Round | 22/09/1980 | RC Strasbourg | - | FC Nantes | 1:2 | ||||
| 12. Round | 25/09/1980 | Nîmes Olympique | - | RC Strasbourg | 4:2 | ||||
| 13. Round | 04/10/1980 | RC Strasbourg | - | Tours FC | 4:1 | ||||
| 14. Round | 14/10/1980 | Girondins Bordeaux | - | RC Strasbourg | 2:1 | ||||
| 15. Round | 17/10/1980 | RC Strasbourg | - | OGC Nice | 2:1 | ||||
| 16. Round | 30/10/1980 | AS Nancy Lorraine | - | RC Strasbourg | 2:0 | ||||
| 19. Round | 22/11/1980 | RC Strasbourg | - | Angers SCO | 2:0 | ||||
| 29. Round | 13/03/1981 | FC Nantes | - | RC Strasbourg | 1:1 | ||||
| 30. Round | 27/03/1981 | RC Strasbourg | - | Nîmes Olympique | 1:0 | ||||
| 31. Round | 06/04/1981 | Tours FC | - | RC Strasbourg | 1:1 | ||||
| 32. Round | 14/04/1981 | RC Strasbourg | - | Girondins Bordeaux | 1:1 | ||||
| 33. Round | 20/04/1981 | OGC Nice | - | RC Strasbourg | 0:0 | ||||
| 34. Round | 04/05/1981 | RC Strasbourg | - | AS Nancy Lorraine | 2:0 | ||||
| 35. Round | 11/05/1981 | Olympique Lyonnais | - | RC Strasbourg | 0:0 |
France