| 1. Round | 17/07/2021 | Lanús | - | Atlético Tucumán | 4:2 | ||||
| 2. Round | 23/07/2021 | Atlético Tucumán | - | Huracán | 1:0 |  |
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| 6. Round | 14/08/2021 | Atlético Tucumán | - | Aldosivi | 2:2 | ||||
| 7. Round | 20/08/2021 | Sarmiento de Junín | - | Atlético Tucumán | 3:0 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán | - | Independiente | 2:0 |  |
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| 9. Round | 30/08/2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | ||||
| 10. Round | 04/09/2021 | Atlético Tucumán | - | Arsenal de Sarandí | 0:0 | ||||
| 11. Round | 14/09/2021 | Central Córdoba SdE | - | Atlético Tucumán | 2:0 | ||||
| 12. Round | 19/09/2021 | Atlético Tucumán | - | Boca Juniors | 1:2 | ||||
| 13. Round | 25/09/2021 | Banfield | - | Atlético Tucumán | 2:0 | ||||
| 15. Round | 12/10/2021 | Talleres de Córdoba | - | Atlético Tucumán | 2:0 | ||||
| 22. Round | 24/11/2021 | Atlético Tucumán | - | Defensa y Justicia | 0:4 | ||||
| 23. Round | 29/11/2021 | Unión de Santa Fe | - | Atlético Tucumán | 3:0 | ||||
| 24. Round | 03/12/2021 | Colón de Santa Fe | - | Atlético Tucumán | 3:0 | ||||
| 25. Round | 11/12/2021 | Atlético Tucumán | - | River Plate | 1:1 |
Argentina