| 1. Round | 18/07/2021 | Vélez Sarsfield | - | Racing Club | 0:0 | ||||
| 3. Round | 28/07/2021 | Vélez Sarsfield | - | Defensa y Justicia | 0:0 |  |
|||
| 4. Round | 03/08/2021 | Atlético Tucumán | - | Vélez Sarsfield | 0:0 |  |
|||
| 7. Round | 21/08/2021 | Vélez Sarsfield | - | Lanús | 5:1 |  |
|||
| 8. Round | 25/08/2021 | Huracán | - | Vélez Sarsfield | 1:1 | ||||
| 9. Round | 29/08/2021 | Vélez Sarsfield | - | Godoy Cruz | 3:0 | ||||
| 10. Round | 07/09/2021 | Vélez Sarsfield | - | Unión de Santa Fe | 4:0 | |
|||
| 11. Round | 14/09/2021 | Gimnasia de La Plata | - | Vélez Sarsfield | 0:0 | ||||
| 12. Round | 18/09/2021 | Vélez Sarsfield | - | Aldosivi | 3:2 | ||||
| 13. Round | 24/09/2021 | Sarmiento de Junín | - | Vélez Sarsfield | 0:1 | ||||
| 14. Round | 03/10/2021 | Vélez Sarsfield | - | Independiente | 3:3 | ||||
| 15. Round | 09/10/2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 | ||||
| 16. Round | 16/10/2021 | Vélez Sarsfield | - | Arsenal de Sarandí | 0:0 | ||||
| 18. Round | 25/10/2021 | Vélez Sarsfield | - | Boca Juniors | 2:0 | ||||
| 19. Round | 30/10/2021 | Banfield | - | Vélez Sarsfield | 2:1 | ||||
| 21. Round | 20/11/2021 | Talleres de Córdoba | - | Vélez Sarsfield | 1:1 |
Argentina
Italy