| 19. Round | 29/01/2022 | FC Barcelona [Women] | - | Real Betis [Women] | 4:0 | ||||
| 20. Round | 02/02/2022 | Real Betis [Women] | - | CD Alavés [Women] | 4:1 |  |
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| 21. Round | 06/02/2022 | Real Madrid [Women] | - | Real Betis [Women] | 1:0 | ||||
| 22. Round | 12/02/2022 | Real Betis [Women] | - | Sporting de Huelva [Women] | 0:0 | ||||
| 23. Round | 06/03/2022 | Sevilla FC [Women] | - | Real Betis [Women] | 0:0 | ||||
| 24. Round | 12/03/2022 | Real Betis [Women] | - | Real Sociedad [Women] | 0:3 | ||||
| 25. Round | 27/03/2022 | UDG Tenerife Sur [Women] | - | Real Betis [Women] | 0:0 | ||||
| 26. Round | 02/04/2022 | Real Betis [Women] | - | Atlético Madrid [Women] | 1:1 | |
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| 27. Round | 17/04/2022 | Madrid CFF [Women] | - | Real Betis [Women] | 2:2 | ||||
| 28. Round | 30/04/2022 | Real Betis [Women] | - | Valencia CF [Women] | 0:0 |  |
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| 29. Round | 08/05/2022 | Villarreal CF [Women] | - | Real Betis [Women] | 2:0 | ||||
| 30. Round | 14/05/2022 | Real Betis [Women] | - | Rayo Vallecano [Women] | 1:3 | |
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England