| 16. Round | 30/10/1980 | Tours FC | - | US Valenciennes-Anzin | 2:3 | ||||
| 17. Round | 07/11/1980 | AS Monaco | - | Tours FC | 1:1 | ||||
| 18. Round | 11/11/1980 | Tours FC | - | FC Metz | 1:1 | ||||
| 19. Round | 22/11/1980 | AS Saint-Étienne | - | Tours FC | 1:2 | ||||
| 22. Round | 12/12/1980 | Tours FC | - | FC Nantes | 2:3 | ||||
| 23. Round | 19/12/1980 | Nîmes Olympique | - | Tours FC | 2:1 | ||||
| 29. Round | 13/03/1981 | Tours FC | - | SC Bastia | 2:2 | ||||
| 30. Round | 27/03/1981 | Angers SCO | - | Tours FC | 2:2 | ||||
| 31. Round | 06/04/1981 | Tours FC | - | RC Strasbourg | 1:1 | ||||
| 32. Round | 14/04/1981 | Paris Saint-Germain | - | Tours FC | 4:1 | ||||
| 33. Round | 20/04/1981 | Tours FC | - | AJ Auxerre | 1:4 |
France