| 4. Round | 03/09/2022 | Villarreal CF B | - | CD Mirandés | 3:0 | ||||
| 5. Round | 10/09/2022 | Levante UD | - | Villarreal CF B | 4:1 | ||||
| 6. Round | 17/09/2022 | Villarreal CF B | - | CD Lugo | 3:1 | ||||
| 7. Round | 24/09/2022 | Málaga CF | - | Villarreal CF B | 1:1 | ||||
| 8. Round | 01/10/2022 | Villarreal CF B | - | Burgos CF | 0:0 | ||||
| 9. Round | 07/10/2022 | Sporting Gijón | - | Villarreal CF B | 3:1 | ||||
| 11. Round | 15/10/2022 | Real Zaragoza | - | Villarreal CF B | 2:1 | ||||
| 13. Round | 30/10/2022 | Albacete | - | Villarreal CF B | 0:0 |  |
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| 14. Round | 02/11/2022 | Villarreal CF B | - | Real Oviedo | 2:1 |
Spain