| 8. Round | 05/10/2020 | US Orléans | - | FC Annecy | 6:1 | ||||
| 9. Round | 09/10/2020 | US Avranches | - | FC Annecy | 1:3 | ||||
| 3. Round | 20/11/2020 | FC Annecy | - | FC Villefranche Beaujolais | 1:0 | ||||
| 11. Round | 24/11/2020 | FC Annecy | - | Sporting Club Lyon | 1:1 | ||||
| 14. Round | 28/11/2020 | FC Annecy | - | US Quevilly-Rouen | 1:2 | ||||
| 12. Round | 11/12/2020 | SO Cholet | - | FC Annecy | 4:2 |  |
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| 5. Round | 15/12/2020 | FC Annecy | - | US Concarneau | 2:4 | ||||
| 16. Round | 18/12/2020 | FC Annecy | - | SC Bastia | 1:1 | ||||
| 17. Round | 08/01/2021 | US Boulogne | - | FC Annecy | 0:1 |  |
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| 18. Round | 26/01/2021 | FC Annecy | - | FC Bourg-Péronnas | 2:2 | |
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| 20. Round | 09/02/2021 | FC Annecy | - | FC Sète | 0:2 | |
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| 25. Round | 13/03/2021 | US Avranches | - | FC Annecy | 2:3 | ||||
| 26. Round | 19/03/2021 | FC Annecy | - | Stade Briochin | 1:1 | |
 |
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| 31. Round | 23/04/2021 | FC Annecy | - | Red Star FC | 0:0 | ||||
| 32. Round | 30/04/2021 | SC Bastia | - | FC Annecy | 0:1 | ||||
| 34. Round | 15/05/2021 | Le Mans FC | - | FC Annecy | 3:2 |
France