| 1. Round | 07/08/2021 | Olympique Lyonnais B | - | AS Monaco B | 1:0 | ||||
| 2. Round | 14/08/2021 | FC Martigues | - | Olympique Lyonnais B | 1:1 | ||||
| 3. Round | 21/08/2021 | Olympique Lyonnais B | - | GFA Rumilly Vallières | 0:2 | ||||
| 4. Round | 28/08/2021 | AS Saint-Priest | - | Olympique Lyonnais B | 1:3 | ||||
| 10. Round | 23/10/2021 | Marignane Gignac FC | - | Olympique Lyonnais B | 4:0 | ||||
| 11. Round | 06/11/2021 | Olympique Lyonnais B | - | SC Toulon | 0:0 | ||||
| 12. Round | 20/11/2021 | Olympique Lyonnais B | - | RC Grasse | 1:0 | ||||
| 14. Round | 11/12/2021 | Olympique Lyonnais B | - | Hyères FC | 3:2 | ||||
| 13. Round | 18/12/2021 | Louhans-Cuiseaux | - | Olympique Lyonnais B | 1:2 | ||||
| 16. Round | 22/01/2022 | Olympique Lyonnais B | - | FC Martigues | 0:1 | ||||
| 23. Round | 26/03/2022 | Olympique Marseille B | - | Olympique Lyonnais B | 0:2 |  |
France