| 2. Round | 05/08/2000 | RC Lens | - | EA Guingamp | 3:2 | ||||
| 3. Round | 12/08/2000 | EA Guingamp | - | FC Nantes | 0:1 | ||||
| 4. Round | 20/08/2000 | AS Monaco | - | EA Guingamp | 1:0 | ||||
| 6. Round | 06/09/2000 | EA Guingamp | - | Toulouse FC | 2:1 |  |
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| 7. Round | 09/09/2000 | Girondins Bordeaux | - | EA Guingamp | 0:2 | ||||
| 12. Round | 21/10/2000 | EA Guingamp | - | RC Strasbourg | 2:1 | ||||
| 13. Round | 29/10/2000 | Stade Rennais | - | EA Guingamp | 1:2 | ||||
| 14. Round | 04/11/2000 | EA Guingamp | - | CS Sedan | 0:3 | ||||
| 28. Round | 03/03/2001 | RC Strasbourg | - | EA Guingamp | 0:1 | ||||
| 33. Round | 12/05/2001 | EA Guingamp | - | ESTAC Troyes | 1:1 |
France