| Group G | 25/10/2018 | Villarreal CF | - | Rapid Wien | 5:0 |  |
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| Group G | 08/11/2018 | Rapid Wien | - | Villarreal CF | 0:0 | |
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| Group G | 29/11/2018 | Rangers FC | - | Villarreal CF | 0:0 | ||||
| Group G | 13/12/2018 | Villarreal CF | - | Spartak Moskva | 2:0 | ||||
| Round of 32 | 14/02/2019 | Sporting CP | - | Villarreal CF | 0:1 | |
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| Round of 16 | 07/03/2019 | Zenit St. Petersburg | - | Villarreal CF | 1:3 | ||||
| Round of 16 | 14/03/2019 | Villarreal CF | - | Zenit St. Petersburg | 2:1 | ||||
| Quarter-finals | 11/04/2019 | Villarreal CF | - | Valencia CF | 1:3 | ||||
| Quarter-finals | 18/04/2019 | Valencia CF | - | Villarreal CF | 2:0 |
Argentina