| 1. Round | 05/09/2021 | SD Eibar [Women] | - | Sevilla FC [Women] | 3:2 | ||||
| 2. Round | 12/09/2021 | Villarreal CF [Women] | - | SD Eibar [Women] | 1:0 | ||||
| 3. Round | 25/09/2021 | SD Eibar [Women] | - | Athletic Club [Women] | 1:2 | ||||
| 4. Round | 29/09/2021 | Levante UD [Women] | - | SD Eibar [Women] | 5:0 | ||||
| 5. Round | 03/10/2021 | SD Eibar [Women] | - | Rayo Vallecano [Women] | 4:0 | ||||
| 6. Round | 10/10/2021 | Real Madrid [Women] | - | SD Eibar [Women] | 2:1 | ||||
| 8. Round | 31/10/2021 | Madrid CFF [Women] | - | SD Eibar [Women] | 1:3 | ||||
| 9. Round | 06/11/2021 | SD Eibar [Women] | - | FC Barcelona [Women] | 0:3 | ||||
| 14. Round | 18/12/2021 | SD Eibar [Women] | - | Real Sociedad [Women] | 2:3 | ||||
| 15. Round | 22/12/2021 | Valencia CF [Women] | - | SD Eibar [Women] | 2:0 |
Spain