| 1. Round | 10/01/2022 | Club Necaxa [Women] | - | UANL Tigres [Women] | 1:3 | ||||
| 2. Round | 20/01/2022 | Santos Laguna [Women] | - | Club Necaxa [Women] | 1:1 | ||||
| 3. Round | 24/01/2022 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 1:0 | ||||
| 4. Round | 28/01/2022 | Club Necaxa [Women] | - | Deportivo Guadalajara [Women] | 0:3 | ||||
| 5. Round | 31/01/2022 | CF América [Women] | - | Club Necaxa [Women] | 3:0 | ||||
| 6. Round | 07/02/2022 | Club Necaxa [Women] | - | Atlas Guadalajara [Women] | 1:1 | ||||
| 7. Round | 13/02/2022 | FC Juárez [Women] | - | Club Necaxa [Women] | 2:3 | ||||
| 8. Round | 01/03/2022 | Club Necaxa [Women] | - | Club León [Women] | 0:0 | ||||
| 10. Round | 15/03/2022 | CF Monterrey [Women] | - | Club Necaxa [Women] | 5:2 | ||||
| 12. Round | 20/03/2022 | Gallos Blancos [Women] | - | Club Necaxa [Women] | 3:0 |  |
Mexico