| 1. Round | 27/09/1942 | Athletic Club | - | Real Betis | 5:0 | ||||
| 2. Round | 04/10/1942 | Real Betis | - | Sevilla FC | 2:5 | ||||
| 3. Round | 11/10/1942 | Granada CF | - | Real Betis | 6:2 | ||||
| 4. Round | 18/10/1942 | Real Betis | - | Real Madrid | 3:1 |  |
|||
| 5. Round | 25/10/1942 | FC Barcelona | - | Real Betis | 4:1 | ||||
| 8. Round | 15/11/1942 | Real Betis | - | Valencia CF | 2:2 | ||||
| 9. Round | 22/11/1942 | Real Betis | - | CD Castellón | 1:1 | ||||
| 11. Round | 06/12/1942 | Real Betis | - | Atlético Aviación | 1:2 | ||||
| 13. Round | 27/12/1942 | Real Betis | - | Real Oviedo | 1:2 | |
|||
| 14. Round | 10/01/1943 | Real Betis | - | Athletic Club | 3:1 | |
|||
| 15. Round | 17/01/1943 | Sevilla FC | - | Real Betis | 5:0 | ||||
| 16. Round | 24/01/1943 | Real Betis | - | Granada CF | 0:1 | ||||
| 21. Round | 28/02/1943 | Valencia CF | - | Real Betis | 8:3 | ||||
| 22. Round | 07/03/1943 | CD Castellón | - | Real Betis | 3:0 | ||||
| 23. Round | 14/03/1943 | Real Betis | - | RC Celta | 1:3 | ||||
| 24. Round | 21/03/1943 | Atlético Aviación | - | Real Betis | 5:1 | |
|||
| 25. Round | 28/03/1943 | Real Betis | - | Espanyol Barcelona | 1:1 | ||||
| 26. Round | 04/04/1943 | Real Oviedo | - | Real Betis | 4:1 |
Spain