1. Round | 15/08/2021 | FC Schalke 04 II | - | 1. FC Köln II | 1:2 | ||||
2. Round | 20/08/2021 | 1. FC Köln II | - | SV Lippstadt 08 | 3:1 | ||||
3. Round | 25/08/2021 | Rot-Weiß Oberhausen | - | 1. FC Köln II | 1:0 | ||||
4. Round | 28/08/2021 | 1. FC Köln II | - | KFC Uerdingen 05 | 8:2 | ||||
7. Round | 15/09/2021 | 1. FC Köln II | - | Alemannia Aachen | 1:3 | ||||
8. Round | 18/09/2021 | Bor. Mönchengladbach II | - | 1. FC Köln II | 3:1 | ||||
9. Round | 25/09/2021 | 1. FC Köln II | - | Sportfreunde Lotte | 4:0 | ||||
10. Round | 01/10/2021 | FC Wegberg-Beeck | - | 1. FC Köln II | 0:1 | ||||
12. Round | 15/10/2021 | Rot Weiss Ahlen | - | 1. FC Köln II | 2:6 | ||||
13. Round | 23/10/2021 | 1. FC Köln II | - | Rot-Weiss Essen | 1:1 | ||||
11. Round | 27/10/2021 | 1. FC Köln II | - | SV Rödinghausen | 2:3 | ||||
15. Round | 05/11/2021 | 1. FC Köln II | - | Wuppertaler SV | 0:3 | ||||
17. Round | 21/11/2021 | 1. FC Köln II | - | Fortuna Düsseldorf II | 1:1 | ||||
19. Round | 04/12/2021 | 1. FC Köln II | - | Preußen Münster | 1:1 | ||||
16. Round | 08/12/2021 | Fortuna Köln | - | 1. FC Köln II | 1:1 | ||||
20. Round | 13/12/2021 | 1. FC Köln II | - | FC Schalke 04 II | 2:1 |