| 2. Round | 16/09/2010 | Newell's Old Boys | - | Estudiantes | 1:0 | ||||
| 2. Round | 23/09/2010 | Estudiantes | - | Newell's Old Boys | 1:1 | ||||
| Round of 16 | 07/10/2010 | Newell's Old Boys | - | Club San José | 6:0 | ||||
| Round of 16 | 22/10/2010 | Club San José | - | Newell's Old Boys | 2:0 |  |
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| Quarter-finals | 03/11/2010 | Newell's Old Boys | - | LDU Quito | 0:0 | ||||
| Quarter-finals | 11/11/2010 | LDU Quito | - | Newell's Old Boys | 1:0 | |
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