| 1. Round | 04/06/2022 | San Lorenzo | - | Independiente | 1:1 | ||||
| 2. Round | 10/06/2022 | Newell's Old Boys | - | San Lorenzo | 0:0 | ||||
| 3. Round | 14/06/2022 | San Lorenzo | - | Arsenal de Sarandí | 3:3 | ||||
| 7. Round | 09/07/2022 | San Lorenzo | - | Boca Juniors | 2:1 | ||||
| 8. Round | 17/07/2022 | Banfield | - | San Lorenzo | 1:1 | ||||
| 9. Round | 20/07/2022 | San Lorenzo | - | Unión de Santa Fe | 2:2 |  |
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| 10. Round | 25/07/2022 | San Lorenzo | - | Talleres de Córdoba | 1:1 | ||||
| 21. Round | 24/09/2022 | Lanús | - | San Lorenzo | 2:0 | ||||
| 27. Round | 22/10/2022 | San Lorenzo | - | Aldosivi | 3:0 |
Argentina