| 3. Round | 05/07/2022 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 3:1 |  |
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| 2. Round | 08/07/2022 | Puebla FC [U18] | - | Santos Laguna [U18] | 0:2 | ||||
| 6. Round | 31/07/2022 | Santos Laguna [U18] | - | Atlas Guadalajara [U18] | 2:0 | ||||
| 1. Round | 03/08/2022 | Santos Laguna [U18] | - | CF Monterrey [U18] | 5:2 | ||||
| 7. Round | 06/08/2022 | Santos Laguna [U18] | - | Cruz Azul [U18] | 2:1 | |
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| 8. Round | 14/08/2022 | UANL Tigres [U18] | - | Santos Laguna [U18] | 0:0 | |
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| 9. Round | 18/08/2022 | Santos Laguna [U18] | - | Club León [U18] | 3:2 | |
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| 10. Round | 21/08/2022 | Pumas UNAM [U18] | - | Santos Laguna [U18] | 2:0 | ||||
| 16. Round | 25/08/2022 | Club Tijuana [U18] | - | Santos Laguna [U18] | 1:1 | ||||
| 11. Round | 28/08/2022 | Santos Laguna [U18] | - | Atlético San Luis [U18] | 0:1 | ||||
| 12. Round | 03/09/2022 | CF Pachuca [U18] | - | Santos Laguna [U18] | 3:1 | ||||
| 13. Round | 06/09/2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 3:0 | ||||
| 14. Round | 10/09/2022 | Gallos Blancos [U18] | - | Santos Laguna [U18] | 1:1 | |
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| 17. Round | 02/10/2022 | Santos Laguna [U18] | - | Mazatlán FC [U18] | 2:1 |
Mexico