| 1. Round | 07/08/2021 | Trélissac FC | - | Moulins Yzeure Foot | 0:2 |  |
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| 2. Round | 14/08/2021 | AS Béziers | - | Trélissac FC | 2:0 | ||||
| 20. Round | 05/03/2022 | Trélissac FC | - | Angers SCO B | 1:1 | ||||
| 22. Round | 19/03/2022 | Trélissac FC | - | Montpellier HSC B | 3:0 | ||||
| 23. Round | 26/03/2022 | FC Chamalières | - | Trélissac FC | 2:1 | ||||
| 25. Round | 16/04/2022 | US Colomiers | - | Trélissac FC | 1:1 | ||||
| 28. Round | 14/05/2022 | Trélissac FC | - | Angoulême CFC | 1:1 | ||||
| 29. Round | 21/05/2022 | Trélissac FC | - | Bergerac Périgord FC | 0:4 |
France