| 20. Round | 12/01/2005 | FC Istres | - | AS Monaco | 0:1 |  |
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| 21. Round | 15/01/2005 | RC Lens | - | FC Istres | 0:1 | ||||
| 22. Round | 22/01/2005 | FC Istres | - | RC Strasbourg | 1:1 | ||||
| 26. Round | 20/02/2005 | FC Istres | - | AJ Auxerre | 1:0 | ||||
| 27. Round | 27/02/2005 | Olympique Marseille | - | FC Istres | 1:1 | ||||
| 28. Round | 05/03/2005 | FC Istres | - | Girondins Bordeaux | 0:1 | ||||
| 29. Round | 12/03/2005 | Olympique Lyonnais | - | FC Istres | 2:1 | |
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| 36. Round | 14/05/2005 | FC Istres | - | Toulouse FC | 1:0 | ||||
| 37. Round | 21/05/2005 | AS Saint-Étienne | - | FC Istres | 2:0 | |
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| 38. Round | 28/05/2005 | FC Istres | - | SM Caen | 3:2 |
France