| 1. Round | 29/07/2005 | Stade Lavallois | - | FC Istres | 0:1 | ||||
| 2. Round | 05/08/2005 | FC Istres | - | EA Guingamp | 0:0 |  |
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| 3. Round | 12/08/2005 | FC Sète | - | FC Istres | 1:2 | ||||
| 4. Round | 16/08/2005 | FC Istres | - | CS Sedan | 2:2 | |
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| 5. Round | 19/08/2005 | Clermont Foot Auvergne | - | FC Istres | 1:0 | |
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| 11. Round | 07/10/2005 | FC Istres | - | FC Gueugnon | 0:1 | ||||
| 12. Round | 14/10/2005 | Montpellier HSC | - | FC Istres | 3:1 | ||||
| 18. Round | 02/12/2005 | Stade de Reims | - | FC Istres | 0:0 | |
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| 19. Round | 16/12/2005 | FC Istres | - | Havre AC | 1:1 | ||||
| 24. Round | 06/02/2006 | FC Istres | - | FC Lorient | 2:1 | ||||
| 25. Round | 10/02/2006 | Dijon FCO | - | FC Istres | 2:0 |
France