| 1. Round | 07/08/2021 | Andrézieux-Bouthéon FC | - | Angers SCO B | 3:1 | ||||
| 10. Round | 23/10/2021 | Andrézieux-Bouthéon FC | - | Trélissac FC | 0:1 | ||||
| 11. Round | 06/11/2021 | Moulins Yzeure Foot | - | Andrézieux-Bouthéon FC | 2:1 | ||||
| 12. Round | 19/11/2021 | Andrézieux-Bouthéon FC | - | AS Béziers | 2:1 | ||||
| 15. Round | 29/01/2022 | Le Puy Foot 43 | - | Andrézieux-Bouthéon FC | 0:0 |  |
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| 17. Round | 05/02/2022 | Montpellier HSC B | - | Andrézieux-Bouthéon FC | 0:2 | ||||
| 18. Round | 12/02/2022 | Andrézieux-Bouthéon FC | - | FC Chamalières | 0:0 | ||||
| 19. Round | 18/02/2022 | Bergerac Périgord FC | - | Andrézieux-Bouthéon FC | 0:0 | ||||
| 23. Round | 25/03/2022 | Andrézieux-Bouthéon FC | - | Angoulême CFC | 1:0 | ||||
| 29. Round | 21/05/2022 | Andrézieux-Bouthéon FC | - | Le Puy Foot 43 | 0:1 | ||||
| 30. Round | 28/05/2022 | Angers SCO B | - | Andrézieux-Bouthéon FC | 2:4 |
Mali