| 1. Round | 23/07/1980 | Lille OSC | - | RC Strasbourg | 3:0 | ||||
| 2. Round | 28/07/1980 | Paris Saint-Germain | - | RC Strasbourg | 1:0 | ||||
| 3. Round | 04/08/1980 | RC Strasbourg | - | AJ Auxerre | 1:0 | ||||
| 4. Round | 11/08/1980 | US Valenciennes-Anzin | - | RC Strasbourg | 1:2 | ||||
| 5. Round | 18/08/1980 | RC Strasbourg | - | AS Saint-Étienne | 0:2 | ||||
| 6. Round | 21/08/1980 | FC Metz | - | RC Strasbourg | 4:1 | ||||
| 7. Round | 25/08/1980 | RC Strasbourg | - | AS Monaco | 0:0 | ||||
| 8. Round | 28/08/1980 | Stade Lavallois | - | RC Strasbourg | 3:1 | ||||
| 9. Round | 08/09/1980 | RC Strasbourg | - | FC Sochaux | 2:0 | ||||
| 10. Round | 11/09/1980 | RC Lens | - | RC Strasbourg | 1:2 | ||||
| 11. Round | 22/09/1980 | RC Strasbourg | - | FC Nantes | 1:2 | ||||
| 12. Round | 25/09/1980 | Nîmes Olympique | - | RC Strasbourg | 4:2 | ||||
| 18. Round | 11/11/1980 | SÉC Bastia | - | RC Strasbourg | 2:0 |
France