| Preliminary | 29/11/2020 | Plateau United | - | Simba SC | 0:1 | ||||
| Preliminary | 05/12/2020 | Simba SC | - | Plateau United | 0:0 | ||||
| 1. Round | 23/12/2020 | FC Platinum | - | Simba SC | 1:0 |  |
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| 1. Round | 06/01/2021 | Simba SC | - | FC Platinum | 4:0 | ||||
| Group A | 12/02/2021 | AS Vita Club | - | Simba SC | 0:1 | |
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| Group A | 23/02/2021 | Simba SC | - | Al Ahly SC | 1:0 | ||||
| Group A | 06/03/2021 | Al Merrikh SC | - | Simba SC | 0:0 | |
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| Group A | 03/04/2021 | Simba SC | - | AS Vita Club | 4:1 | ||||
| Group A | 09/04/2021 | Al Ahly SC | - | Simba SC | 1:0 | ||||
| Quarter-finals | 15/05/2021 | Kaizer Chiefs | - | Simba SC | 4:0 | |
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| Quarter-finals | 22/05/2021 | Simba SC | - | Kaizer Chiefs | 3:0 |
Ivory Coast