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| 1st(1st leg) | Forest Rangers | - | AS Bouenguidi | 0:0 (0:0) | ||
| 2nd (2nd leg) | AS Bouenguidi | - | Forest Rangers | 2:0 (0:0) | ||
| 1st(1st leg): 28/11/2020 13:00 | 2nd (2nd leg): 05/12/2020 14:30 | Winner: AS Bouenguidi | ||||
| 1st(1st leg) | Vipers SC | - | Al Hilal Omdurman | 0:1 (0:1) | ||
| 2nd (2nd leg) | Al Hilal Omdurman | - | Vipers SC | 1:0 (0:0) | ||
| 1st(1st leg): 28/11/2020 13:00 | 2nd (2nd leg): 06/12/2020 13:00 | Winner: Al Hilal Omdurman | ||||
| 1st(1st leg) | APR FC | - | Gor Mahia FC | 2:1 (1:1) | ||
| 2nd (2nd leg) | Gor Mahia FC | - | APR FC | 3:1 (1:0) | ||
| 1st(1st leg): 28/11/2020 13:00 | 2nd (2nd leg): 05/12/2020 13:00 | Winner: Gor Mahia FC | ||||
| 1st(1st leg) | Jwaneng Galaxy | - | US Zilimadjou | 4:0 (2:0) | ||
| 2nd (2nd leg) | US Zilimadjou | - | Jwaneng Galaxy | 1:1 (0:0) | ||
| 1st(1st leg): 28/11/2020 13:30 | 2nd (2nd leg): 06/12/2020 12:00 | Winner: Jwaneng Galaxy | ||||
| 1st(1st leg) | Mlandege | - | CS Sfaxien | 0:5 (0:2) | ||
| 2nd (2nd leg) | CS Sfaxien | - | Mlandege | 3:1 (0:0) | ||
| 1st(1st leg): 28/11/2020 13:30 | 2nd (2nd leg): 05/12/2020 14:00 | Winner: CS Sfaxien | ||||
| 1st(1st leg) | CD Costa do Sol | - | FC Platinum | 1:2 (0:0) | ||
| 2nd (2nd leg) | FC Platinum | - | CD Costa do Sol | 2:0 (0:0) | ||
| 1st(1st leg): 28/11/2020 13:30 | 2nd (2nd leg): 05/12/2020 13:00 | Winner: FC Platinum | ||||
| 1st(1st leg) | Buffles du Borgou FC | - | MC Alger | 1:1 (0:1) | ||
| 2nd (2nd leg) | MC Alger | - | Buffles du Borgou FC | 5:1 (2:1) | ||
| 1st(1st leg): 28/11/2020 14:00 | 2nd (2nd leg): 19/12/2020 19:45 | Winner: MC Alger | ||||
| 1st(1st leg) | Al Ahly Benghazi | - | Mekelle 70 Enderta | 3:0 dec. | ||
| 2nd (2nd leg) | Mekelle 70 Enderta | - | Al Ahly Benghazi | 0:3 dec. | ||
| 1st(1st leg): 28/11/2020 18:00 | 2nd (2nd leg): 05/12/2020 13:00 | Winner: Al Ahly Benghazi | ||||
| 1st(1st leg) | Young Buffaloes | - | Le Messager Ngozi | 0:0 (0:0) | ||
| 2nd (2nd leg) | Le Messager Ngozi | - | Young Buffaloes | 1:1 (1:1) | ||
| 1st(1st leg): 29/11/2020 13:00 | 2nd (2nd leg): 06/12/2020 13:00 | Winner: Young Buffaloes | ||||
| 1st(1st leg) | PWD Bamenda | - | Kaizer Chiefs | 0:1 (0:0) | ||
| 2nd (2nd leg) | Kaizer Chiefs | - | PWD Bamenda | 0:0 (0:0) | ||
| 1st(1st leg): 29/11/2020 14:00 | 2nd (2nd leg): 05/12/2020 17:00 | Winner: Kaizer Chiefs | ||||
| 1st(1st leg) | Bantu Mafeteng | - | Nkana FC | 0:1 (0:1) | ||
| 2nd (2nd leg) | Nkana FC | - | Bantu Mafeteng | 0:0 (0:0) | ||
| 1st(1st leg): 29/11/2020 14:00 | 2nd (2nd leg): 05/12/2020 13:00 | Winner: Nkana FC | ||||
| 1st(1st leg) | AS Otôho | - | Al Merrikh SC | 1:1 (0:0) | ||
| 2nd (2nd leg) | Al Merrikh SC | - | AS Otôho | 2:0 (0:0) | ||
| 1st(1st leg): 29/11/2020 14:30 | 2nd (2nd leg): 04/12/2020 13:00 | Winner: Al Merrikh SC | ||||
| 1st(1st leg) | FC Akonangui | - | Petro Atlético | 0:1 (0:1) | ||
| 2nd (2nd leg) | Petro Atlético | - | FC Akonangui | 2:2 (1:0) | ||
| 1st(1st leg): 29/11/2020 14:30 | 2nd (2nd leg): 05/12/2020 16:00 | Winner: Petro Atlético | ||||
| 1st(1st leg) | AS SONIDEP | - | Mogadishu City Club | 2:0 (0:0) | ||
| 2nd (2nd leg) | Mogadishu City Club | - | AS SONIDEP | 0:2 (0:2) | ||
| 1st(1st leg): 29/11/2020 15:00 | 2nd (2nd leg): 05/12/2020 14:15 | Winner: AS SONIDEP | ||||
| 1st(1st leg) | Gazelle FC | - | CF Garde Républicaine | 3:0 dec. | ||
| 2nd (2nd leg) | CF Garde Républicaine | - | Gazelle FC | 0:3 dec. | ||
| 1st(1st leg): 29/11/2020 15:00 | 2nd (2nd leg): 04/12/2020 14:00 | Winner: Gazelle FC | ||||
| 1st(1st leg) | Plateau United | - | Simba SC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Simba SC | - | Plateau United | 0:0 (0:0) | ||
| 1st(1st leg): 29/11/2020 15:00 | 2nd (2nd leg): 05/12/2020 14:15 | Winner: Simba SC | ||||
| 1st(1st leg) | RC Abidjan | - | ASKO Kara | 1:0 (1:0) | ||
| 2nd (2nd leg) | ASKO Kara | - | RC Abidjan | 2:1 (0:1) | ||
| 1st(1st leg): 29/11/2020 16:00 | 2nd (2nd leg): 06/12/2020 15:30 | Winner: RC Abidjan | ||||
| 1st(1st leg) | Rahimo FC | - | Enyimba Aba | 0:1 (0:0) | ||
| 2nd (2nd leg) | Enyimba Aba | - | Rahimo FC | 1:1 (0:0) | ||
| 1st(1st leg): 29/11/2020 16:00 | 2nd (2nd leg): 06/12/2020 15:00 | Winner: Enyimba Aba | ||||
| 1st(1st leg) | FC Nouadhibou | - | Asante Kotoko | 1:1 (1:1) | ||
| 2nd (2nd leg) | Asante Kotoko | - | FC Nouadhibou | 2:0 dec. | ||
| 1st(1st leg): 29/11/2020 16:00 | 2nd (2nd leg): 06/12/2020 16:00 | Winner: Asante Kotoko | ||||
| 1st(1st leg) | CR Bélouizdad | - | Al Nasr Benghazi | 2:0 (1:0) | ||
| 2nd (2nd leg) | Al Nasr Benghazi | - | CR Bélouizdad | 0:2 (0:1) | ||
| 1st(1st leg): 29/11/2020 16:00 | 2nd (2nd leg): 06/12/2020 16:00 | Winner: CR Bélouizdad | ||||
| 1st(1st leg) | AS Ashanti Golden Boys | - | Stade Malien | 1:2 (0:2) | ||
| 2nd (2nd leg) | Stade Malien | - | AS Ashanti Golden Boys | 2:0 dec. | ||
| 1st(1st leg): 29/11/2020 16:30 | 2nd (2nd leg): 05/12/2020 16:15 | Winner: Stade Malien | ||||
| 1st(1st leg) | Armed Forces | - | Teungueth FC | 1:1 (1:0) | ||
| 2nd (2nd leg) | Teungueth FC | - | Armed Forces | 2:0 (0:0) | ||
| 1st(1st leg): 29/11/2020 16:30 | 2nd (2nd leg): 06/12/2020 17:00 | Winner: Teungueth FC | ||||
