| 1. Round | 04/09/2021 | CA Osasuna B | - | CD Tropezón | 2:0 | ||||
| 2. Round | 12/09/2021 | CD Tropezón | - | SD Gernika | 0:2 | ||||
| 3. Round | 18/09/2021 | UD Logroñés Promesas | - | CD Tropezón | 4:1 |  |
|||
| 7. Round | 17/10/2021 | CD Tropezón | - | CD Laredo | 1:0 | |
|||
| 8. Round | 24/10/2021 | Real Sociedad C | - | CD Tropezón | 5:0 |  |
|||
| 11. Round | 14/11/2021 | CD Tropezón | - | Burgos Promesas | 1:1 | |
|||
| 12. Round | 21/11/2021 | Racing Rioja CF | - | CD Tropezón | 4:0 | |
|||
| 16. Round | 19/12/2021 | Rayo Cantabria | - | CD Tropezón | 2:0 |
Spain