| 13. Round | 04/12/2021 | Stade Montois | - | Andrézieux-Bouthéon FC | 1:2 |  |
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| 14. Round | 11/12/2021 | Andrézieux-Bouthéon FC | - | Bourges Foot 18 | 2:1 | ||||
| 7. Round | 07/01/2022 | FC Nantes B | - | Andrézieux-Bouthéon FC | 1:0 | ||||
| 16. Round | 22/01/2022 | Andrézieux-Bouthéon FC | - | Vendée Les Herbiers | 1:2 | ||||
| 15. Round | 29/01/2022 | Le Puy Foot 43 | - | Andrézieux-Bouthéon FC | 0:0 | ||||
| 17. Round | 05/02/2022 | Montpellier HSC B | - | Andrézieux-Bouthéon FC | 0:2 | ||||
| 18. Round | 12/02/2022 | Andrézieux-Bouthéon FC | - | FC Chamalières | 0:0 | ||||
| 19. Round | 18/02/2022 | Bergerac Périgord FC | - | Andrézieux-Bouthéon FC | 0:0 | ||||
| 20. Round | 05/03/2022 | US Colomiers | - | Andrézieux-Bouthéon FC | 3:3 | |
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| 25. Round | 16/04/2022 | Andrézieux-Bouthéon FC | - | Moulins Yzeure Foot | 2:0 |  |
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| 26. Round | 22/04/2022 | AS Béziers | - | Andrézieux-Bouthéon FC | 3:1 | ||||
| 27. Round | 30/04/2022 | Andrézieux-Bouthéon FC | - | Stade Montois | 3:3 | |
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| 28. Round | 14/05/2022 | Bourges Foot 18 | - | Andrézieux-Bouthéon FC | 1:0 | ||||
| 29. Round | 21/05/2022 | Andrézieux-Bouthéon FC | - | Le Puy Foot 43 | 0:1 |
Niger
Mali