| 1. Round | 27/08/2021 | Olympique Lyonnais [Women] | - | Stade de Reims [Women] | 3:0 | ||||
| 2. Round | 05/09/2021 | Olympique Lyonnais [Women] | - | AS Saint-Étienne [Women] | 6:0 | ||||
| 3. Round | 12/09/2021 | Olympique Lyonnais [Women] | - | Dijon FCO [Women] | 6:0 |  |
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| 4. Round | 24/09/2021 | Olympique Lyonnais [Women] | - | EA Guingamp [Women] | 4:0 | ||||
| 5. Round | 01/10/2021 | Girondins Bordeaux [Women] | - | Olympique Lyonnais [Women] | 1:4 | ||||
| 6. Round | 17/10/2021 | Olympique Lyonnais [Women] | - | Montpellier HSC [Women] | 5:0 | ||||
| 7. Round | 31/10/2021 | ASJ Soyaux [Women] | - | Olympique Lyonnais [Women] | 1:6 | |
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| 8. Round | 14/11/2021 | Olympique Lyonnais [Women] | - | Paris Saint-Germain [Women] | 6:1 | ||||
| 9. Round | 21/11/2021 | GPSO 92 Issy [Women] | - | Olympique Lyonnais [Women] | 0:4 | |
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| 10. Round | 05/12/2021 | Olympique Lyonnais [Women] | - | FC Fleury 91 [Women] | 4:0 | ||||
| 11. Round | 12/12/2021 | Paris FC [Women] | - | Olympique Lyonnais [Women] | 1:2 |
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