| 1. Round | 10/01/2022 | FC Juárez [Women] | - | Atlético San Luis [Women] | 0:1 | ||||
| 2. Round | 18/01/2022 | Club León [Women] | - | FC Juárez [Women] | 1:3 |  |
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| 5. Round | 01/02/2022 | FC Juárez [Women] | - | CF Monterrey [Women] | 1:3 | |
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| 6. Round | 07/02/2022 | CF Pachuca [Women] | - | FC Juárez [Women] | 3:1 | ||||
| 7. Round | 13/02/2022 | FC Juárez [Women] | - | Club Necaxa [Women] | 2:3 | ||||
| 3. Round | 24/02/2022 | FC Juárez [Women] | - | UANL Tigres [Women] | 1:2 | ||||
| 8. Round | 27/02/2022 | FC Juárez [Women] | - | Deportivo Toluca [Women] | 0:1 | ||||
| 10. Round | 13/03/2022 | Puebla FC [Women] | - | FC Juárez [Women] | 2:1 | ||||
| 11. Round | 17/03/2022 | FC Juárez [Women] | - | Mazatlán FC [Women] | 1:1 | ||||
| 14. Round | 01/04/2022 | CF América [Women] | - | FC Juárez [Women] | 2:1 | ||||
| 9. Round | 11/04/2022 | Deportivo Guadalajara [Women] | - | FC Juárez [Women] | 0:0 | ||||
| 16. Round | 26/04/2022 | Santos Laguna [Women] | - | FC Juárez [Women] | 3:1 | ||||
| 17. Round | 03/05/2022 | Club Tijuana [Women] | - | FC Juárez [Women] | 3:2 |  |
Mexico