| 1. Round | 22/08/2021 | LB Châteauroux [Youth] | - | Tours FC [Youth] | 3:1 | ||||
| 2. Round | 29/08/2021 | Tours FC [Youth] | - | Le Mans FC [Youth] | 2:3 | ||||
| 3. Round | 04/09/2021 | US Avranches [Youth] | - | Tours FC [Youth] | 4:0 | ||||
| 6. Round | 26/09/2021 | Tours FC [Youth] | - | USSA Vertou [Youth] | 0:3 | ||||
| 7. Round | 02/10/2021 | Stade Lavallois [Youth] | - | Tours FC [Youth] | 3:1 | ||||
| 11. Round | 14/11/2021 | Stade Brestois 29 [Youth] | - | Tours FC [Youth] | 4:1 |  |
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| 12. Round | 20/11/2021 | Tours FC [Youth] | - | Angers SCO [Youth] | 1:2 |
France