| 1. Round | 05/09/2021 | Madrid CFF [Women] | - | Athletic Club [Women] | 0:2 | ||||
| 3. Round | 25/09/2021 | SD Eibar [Women] | - | Athletic Club [Women] | 1:2 | ||||
| 4. Round | 29/09/2021 | Valencia CF [Women] | - | Athletic Club [Women] | 1:3 |  |
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| 10. Round | 14/11/2021 | Rayo Vallecano [Women] | - | Athletic Club [Women] | 0:2 | ||||
| 12. Round | 04/12/2021 | FC Barcelona [Women] | - | Athletic Club [Women] | 4:0 | ||||
| 13. Round | 11/12/2021 | Athletic Club [Women] | - | CD Alavés [Women] | 4:1 | ||||
| 14. Round | 18/12/2021 | UDG Tenerife Sur [Women] | - | Athletic Club [Women] | 2:0 | |
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| 16. Round | 09/01/2022 | Real Sociedad [Women] | - | Athletic Club [Women] | 1:0 | |
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| 18. Round | 16/01/2022 | Levante UD [Women] | - | Athletic Club [Women] | 2:3 |
France