| 1. Round | 09/08/2008 | AS Nancy Lorraine | - | Lille OSC | 0:0 | ||||
| 2. Round | 16/08/2008 | Lille OSC | - | Le Mans UC 72 | 1:3 | ||||
| 3. Round | 24/08/2008 | Stade Rennais | - | Lille OSC | 2:1 | ||||
| 4. Round | 31/08/2008 | Lille OSC | - | Girondins Bordeaux | 2:1 | ||||
| 8. Round | 04/10/2008 | Lille OSC | - | Valenciennes FC | 1:0 | ||||
| 9. Round | 18/10/2008 | Olympique Lyonnais | - | Lille OSC | 2:2 | ||||
| 11. Round | 29/10/2008 | Grenoble Foot 38 | - | Lille OSC | 0:0 | ||||
| 12. Round | 01/11/2008 | Lille OSC | - | FC Nantes | 2:0 | ||||
| 15. Round | 23/11/2008 | Olympique Marseille | - | Lille OSC | 2:2 | ||||
| 17. Round | 06/12/2008 | Lille OSC | - | Toulouse FC | 1:1 | ||||
| 18. Round | 14/12/2008 | OGC Nice | - | Lille OSC | 0:1 | ||||
| 19. Round | 20/12/2008 | Lille OSC | - | Havre AC | 3:1 | ||||
| 21. Round | 18/01/2009 | Lille OSC | - | Stade Rennais | 1:0 | ||||
| 22. Round | 01/02/2009 | Girondins Bordeaux | - | Lille OSC | 2:2 | ||||
| 25. Round | 22/02/2009 | Lille OSC | - | AS Monaco | 2:1 |  |
|||
| 26. Round | 28/02/2009 | Valenciennes FC | - | Lille OSC | 2:0 |
France