| 1. Round | 07/08/2010 | Stade Rennais | - | Lille OSC | 1:1 | ||||
| 3. Round | 22/08/2010 | FC Sochaux | - | Lille OSC | 0:0 | ||||
| 5. Round | 11/09/2010 | RC Lens | - | Lille OSC | 1:4 | ||||
| 6. Round | 19/09/2010 | Lille OSC | - | AJ Auxerre | 1:0 | ||||
| 8. Round | 03/10/2010 | Lille OSC | - | Montpellier HSC | 3:1 | ||||
| 11. Round | 31/10/2010 | Valenciennes FC | - | Lille OSC | 1:1 | ||||
| 20. Round | 15/01/2011 | OGC Nice | - | Lille OSC | 0:2 | ||||
| 22. Round | 06/02/2011 | AJ Auxerre | - | Lille OSC | 1:1 | ||||
| 28. Round | 19/03/2011 | Stade Brestois 29 | - | Lille OSC | 1:2 | ||||
| 34. Round | 07/05/2011 | AS Nancy Lorraine | - | Lille OSC | 0:1 | ||||
| 35. Round | 10/05/2011 | AS Saint-Étienne | - | Lille OSC | 1:2 | ||||
| 38. Round | 29/05/2011 | Lille OSC | - | Stade Rennais | 3:2 |
France