| 1. Round | 23/07/1980 | Lille OSC | - | RC Strasbourg | 3:0 | ||||
| 2. Round | 28/07/1980 | AS Monaco | - | Lille OSC | 1:2 | ||||
| 3. Round | 04/08/1980 | Lille OSC | - | Paris Saint-Germain | 2:2 | ||||
| 4. Round | 11/08/1980 | Stade Lavallois | - | Lille OSC | 4:2 | ||||
| 7. Round | 25/08/1980 | Lille OSC | - | US Valenciennes-Anzin | 1:2 |  |
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| 8. Round | 28/08/1980 | AS Saint-Étienne | - | Lille OSC | 3:1 | ||||
| 23. Round | 19/12/1980 | AJ Auxerre | - | Lille OSC | 2:2 |  |
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| 24. Round | 23/01/1981 | Lille OSC | - | Tours FC | 1:1 | ||||
| 25. Round | 29/01/1981 | US Valenciennes-Anzin | - | Lille OSC | 0:3 | |
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| 26. Round | 05/02/1981 | Lille OSC | - | AS Saint-Étienne | 1:3 | ||||
| 27. Round | 20/02/1981 | RC Lens | - | Lille OSC | 0:0 | ||||
| 28. Round | 26/02/1981 | Lille OSC | - | FC Nantes | 0:3 | ||||
| 29. Round | 13/03/1981 | FC Metz | - | Lille OSC | 3:0 | ||||
| 33. Round | 20/04/1981 | Nîmes Olympique | - | Lille OSC | 2:1 | ||||
| 37. Round | 28/05/1981 | SC Bastia | - | Lille OSC | 5:1 | ||||
| 38. Round | 01/06/1981 | RC Strasbourg | - | Lille OSC | 3:2 |
France