| 7. Round | 10/09/2021 | Club Brugge KV | - | KV Oostende | 3:0 |  |
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| 11. Round | 16/10/2021 | KV Oostende | - | Cercle Brugge | 2:1 | ||||
| 12. Round | 23/10/2021 | KV Kortrijk | - | KV Oostende | 1:0 |  |
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| 13. Round | 29/10/2021 | KV Oostende | - | KV Mechelen | 2:4 | ||||
| 14. Round | 05/11/2021 | Oud-Heverlee Leuven | - | KV Oostende | 1:0 | ||||
| 15. Round | 21/11/2021 | KV Oostende | - | Union Saint-Gilloise | 1:7 | ||||
| 16. Round | 28/11/2021 | Royal Antwerp FC | - | KV Oostende | 3:0 | ||||
| 17. Round | 04/12/2021 | KV Oostende | - | KAS Eupen | 2:1 | ||||
| 18. Round | 10/12/2021 | Sporting Charleroi | - | KV Oostende | 1:0 | ||||
| 19. Round | 14/12/2021 | KV Oostende | - | KV Kortrijk | 0:2 | ||||
| 20. Round | 18/12/2021 | K Beerschot VA | - | KV Oostende | 0:2 | |
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| 22. Round | 09/02/2022 | SV Zulte Waregem | - | KV Oostende | 0:0 | ||||
| 27. Round | 12/02/2022 | KV Mechelen | - | KV Oostende | 3:0 | ||||
| 28. Round | 19/02/2022 | KV Oostende | - | Standard Liège | 1:0 | ||||
| 29. Round | 26/02/2022 | KV Oostende | - | Sint-Truidense VV | 0:0 | ||||
| 30. Round | 06/03/2022 | RSC Anderlecht | - | KV Oostende | 3:0 | |
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| 31. Round | 12/03/2022 | KV Oostende | - | Club Brugge KV | 1:3 |
France