| 4. Round | 19/09/2020 | RC Lens | - | Girondins Bordeaux | 2:1 |  |
|||
| 5. Round | 27/09/2020 | Nîmes Olympique | - | RC Lens | 1:1 | ||||
| 10. Round | 08/11/2020 | RC Lens | - | Stade de Reims | 4:4 | ||||
| 14. Round | 12/12/2020 | RC Lens | - | Montpellier HSC | 2:3 | ||||
| 15. Round | 16/12/2020 | AS Monaco | - | RC Lens | 0:3 | ||||
| 17. Round | 23/12/2020 | RC Lens | - | Stade Brestois 29 | 2:1 | ||||
| 18. Round | 06/01/2021 | Olympique Lyonnais | - | RC Lens | 3:2 | ||||
| 20. Round | 17/01/2021 | FC Nantes | - | RC Lens | 1:1 | |
|||
| 9. Round | 20/01/2021 | Olympique Marseille | - | RC Lens | 0:1 | ||||
| 21. Round | 23/01/2021 | RC Lens | - | OGC Nice | 0:1 | |
|||
| 22. Round | 30/01/2021 | Montpellier HSC | - | RC Lens | 1:2 | ||||
| 23. Round | 03/02/2021 | RC Lens | - | Olympique Marseille | 2:2 | ||||
| 26. Round | 21/02/2021 | RC Lens | - | Dijon FCO | 2:1 | ||||
| 31. Round | 03/04/2021 | RC Lens | - | Olympique Lyonnais | 1:1 | |
|||
| 32. Round | 11/04/2021 | RC Lens | - | FC Lorient | 4:1 | ||||
| 33. Round | 18/04/2021 | Stade Brestois 29 | - | RC Lens | 1:1 |  |
|||
| 35. Round | 01/05/2021 | Paris Saint-Germain | - | RC Lens | 2:1 | ||||
| 36. Round | 07/05/2021 | RC Lens | - | Lille OSC | 0:3 | |
France