| 17. Round | 05/02/2022 | US Saint-Malo | - | FC Lorient B | 2:0 | ||||
| 18. Round | 12/02/2022 | EA Guingamp B | - | US Saint-Malo | 0:0 | ||||
| 19. Round | 19/02/2022 | US Saint-Malo | - | AS Poissy | 2:0 |  |
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| 20. Round | 05/03/2022 | C'Chartres Football | - | US Saint-Malo | 2:1 | ||||
| 21. Round | 12/03/2022 | US Saint-Malo | - | Châteaubriant Voltigeurs | 3:2 |  |
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| 22. Round | 19/03/2022 | Vannes OC | - | US Saint-Malo | 3:2 | |
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| 23. Round | 26/03/2022 | US Saint-Malo | - | US Granvillaise | 1:0 | ||||
| 24. Round | 09/04/2022 | SO Romorantin | - | US Saint-Malo | 2:1 | |
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| 25. Round | 16/04/2022 | US Saint-Malo | - | FC Rouen 1899 | 1:4 | ||||
| 26. Round | 23/04/2022 | AS Vitré | - | US Saint-Malo | 2:2 | |
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| 27. Round | 30/04/2022 | US Saint-Malo | - | FC Versailles | 1:2 | ||||
| 29. Round | 21/05/2022 | Stade Plabennec | - | US Saint-Malo | 0:6 | |
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| 30. Round | 28/05/2022 | US Saint-Malo | - | St-Pryvé St-Hilaire | 1:0 |
France