| 1. Round | 07/08/2021 | Stade Plabennec | - | SM Caen B | 0:1 | ||||
| 2. Round | 14/08/2021 | SM Caen B | - | Vannes OC | 0:0 | ||||
| 5. Round | 04/09/2021 | Blois Foot 41 | - | SM Caen B | 2:1 | ||||
| 7. Round | 18/09/2021 | FC Lorient B | - | SM Caen B | 0:1 | ||||
| 9. Round | 09/10/2021 | EA Guingamp B | - | SM Caen B | 1:1 | ||||
| 11. Round | 06/11/2021 | AS Poissy | - | SM Caen B | 1:0 | ||||
| 13. Round | 04/12/2021 | C'Chartres Football | - | SM Caen B | 4:0 | ||||
| 16. Round | 22/01/2022 | Vannes OC | - | SM Caen B | 1:4 | ||||
| 15. Round | 29/01/2022 | SM Caen B | - | Châteaubriant Voltigeurs | 4:0 | ||||
| 19. Round | 19/02/2022 | SM Caen B | - | Blois Foot 41 | 3:2 | ||||
| 21. Round | 12/03/2022 | SM Caen B | - | FC Lorient B | 1:3 | ||||
| 24. Round | 09/04/2022 | AS Vitré | - | SM Caen B | 2:0 |
France