| 2. Round | 23/08/2021 | Getafe CF | - | Sevilla FC | 0:1 | ||||
| 3. Round | 28/08/2021 | Elche CF | - | Sevilla FC | 1:1 | ||||
| 7. Round | 25/09/2021 | Sevilla FC | - | Espanyol Barcelona | 2:0 | ||||
| 8. Round | 03/10/2021 | Granada CF | - | Sevilla FC | 1:0 | ||||
| 9. Round | 17/10/2021 | RC Celta | - | Sevilla FC | 0:1 | ||||
| 10. Round | 24/10/2021 | Sevilla FC | - | Levante UD | 5:3 | ||||
| 11. Round | 27/10/2021 | RCD Mallorca | - | Sevilla FC | 1:1 | ||||
| 14. Round | 20/11/2021 | Sevilla FC | - | CD Alavés | 2:2 |
Spain
