| 22. Round | 08/02/2025 | AC Ajaccio | - | EA Guingamp | 0:3 |  |
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| 23. Round | 15/02/2025 | EA Guingamp | - | FC Metz | 0:3 | ||||
| 26. Round | 07/03/2025 | EA Guingamp | - | Clermont Foot 63 | 3:1 | ||||
| 27. Round | 14/03/2025 | ESTAC Troyes | - | EA Guingamp | 0:1 | ||||
| 28. Round | 29/03/2025 | EA Guingamp | - | Stade Lavallois | 2:0 | ||||
| 29. Round | 07/04/2025 | USL Dunkerque | - | EA Guingamp | 3:1 |  |
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| 31. Round | 18/04/2025 | Amiens SC | - | EA Guingamp | 3:2 | ||||
| 32. Round | 25/04/2025 | EA Guingamp | - | FC Martigues | 2:1 | ||||
| 33. Round | 02/05/2025 | EA Guingamp | - | SC Bastia | 2:2 | ||||
| 34. Round | 10/05/2025 | Pau FC | - | EA Guingamp | 1:3 |
France