| 5. Round | 25/06/2022 | Tigre II | - | San Lorenzo II | 3:2 | ||||
| 6. Round | 03/07/2022 | San Lorenzo II | - | Barracas Central II | 1:0 | ||||
| 7. Round | 08/07/2022 | Boca Juniors II | - | San Lorenzo II | 2:1 |  |
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| 8. Round | 13/07/2022 | San Lorenzo II | - | Banfield II | 0:1 | ||||
| 13. Round | 12/08/2022 | San Lorenzo II | - | Patronato de Paraná II | 1:2 |
Argentina