| 1. Round | 16/07/2021 | Vélez Sarsfield II | - | Racing Club II | 1:1 | ||||
| 2. Round | 23/07/2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Round | 26/07/2021 | Vélez Sarsfield II | - | Defensa y Justicia II | 0:0 | ||||
| 5. Round | 06/08/2021 | Vélez Sarsfield II | - | Colón de Santa Fe II | 0:2 | ||||
| 6. Round | 13/08/2021 | River Plate II | - | Vélez Sarsfield II | 1:2 | ||||
| 7. Round | 20/08/2021 | Vélez Sarsfield II | - | Lanús II | 1:0 | ||||
| 8. Round | 25/08/2021 | Huracán II | - | Vélez Sarsfield II | 2:2 | ||||
| 11. Round | 10/09/2021 | Gimnasia de La Plata II | - | Vélez Sarsfield II | 2:3 | ||||
| 13. Round | 24/09/2021 | Sarmiento de Junín II | - | Vélez Sarsfield II | 0:4 | ||||
| 14. Round | 01/10/2021 | Vélez Sarsfield II | - | Independiente II | 0:0 | ||||
| 15. Round | 08/10/2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 17. Round | 19/10/2021 | Central Córdoba SdE II | - | Vélez Sarsfield II | 2:0 | ||||
| 19. Round | 29/10/2021 | Banfield II | - | Vélez Sarsfield II | 1:2 | ||||
| 9. Round | 11/11/2021 | Vélez Sarsfield II | - | Godoy Cruz II | 3:0 |  |
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| 23. Round | 29/11/2021 | Estudiantes II | - | Vélez Sarsfield II | 2:3 | ||||
| 25. Round | 09/12/2021 | Platense II | - | Vélez Sarsfield II | 3:1 |
Argentina