| 5. Round | 26/09/2021 | SAS Épinal [Youth B] | - | AS Nancy Lorraine [Youth B] | 0:3 | ||||
| 6. Round | 03/10/2021 | RC Strasbourg [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 7. Round | 10/10/2021 | SAS Épinal [Youth B] | - | ASPTT Dijon [Youth B] | 0:3 | ||||
| 10. Round | 14/11/2021 | AJ Auxerre [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 12. Round | 28/11/2021 | Olympique Lyonnais [Youth B] | - | SAS Épinal [Youth B] | 5:0 | ||||
| 13. Round | 05/12/2021 | SAS Épinal [Youth B] | - | FC Sochaux [Youth B] | 0:6 | ||||
| 16. Round | 27/02/2022 | SAS Épinal [Youth B] | - | FC Lyon [Youth B] | 0:2 | ||||
| 18. Round | 06/03/2022 | SAS Épinal [Youth B] | - | RC Strasbourg [Youth B] | 0:6 | ||||
| 19. Round | 13/03/2022 | ASPTT Dijon [Youth B] | - | SAS Épinal [Youth B] | 2:2 | ||||
| 20. Round | 20/03/2022 | SAS Épinal [Youth B] | - | FC Bourg-Péronnas [Youth B] | 1:1 | ||||
| 21. Round | 27/03/2022 | Racing Besançon [Youth B] | - | SAS Épinal [Youth B] | 2:2 |
France