| 5. Round | 11/09/2010 | AJ Auxerre | - | SM Caen | 1:1 | ||||
| 6. Round | 18/09/2010 | FC Lorient | - | SM Caen | 0:1 | ||||
| 12. Round | 06/11/2010 | AC Arles-Avignon | - | SM Caen | 3:2 | ||||
| 13. Round | 13/11/2010 | SM Caen | - | Lille OSC | 2:5 | ||||
| 15. Round | 28/11/2010 | SM Caen | - | FC Sochaux | 0:3 | ||||
| 19. Round | 22/12/2010 | SM Caen | - | Stade Rennais | 1:0 | ||||
| 18. Round | 22/01/2011 | RC Lens | - | SM Caen | 2:0 | ||||
| 21. Round | 29/01/2011 | SM Caen | - | AJ Auxerre | 2:0 | ||||
| 23. Round | 12/02/2011 | Girondins Bordeaux | - | SM Caen | 1:2 |  |
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| 24. Round | 19/02/2011 | SM Caen | - | Valenciennes FC | 2:2 | ||||
| 25. Round | 26/02/2011 | AS Monaco | - | SM Caen | 2:2 | ||||
| 26. Round | 05/03/2011 | SM Caen | - | AS Saint-Étienne | 1:0 | ||||
| 27. Round | 12/03/2011 | AS Nancy Lorraine | - | SM Caen | 2:0 | ||||
| 28. Round | 20/03/2011 | SM Caen | - | AC Arles-Avignon | 2:0 | ||||
| 29. Round | 02/04/2011 | Lille OSC | - | SM Caen | 3:1 | ||||
| 33. Round | 01/05/2011 | OGC Nice | - | SM Caen | 0:4 | ||||
| 36. Round | 15/05/2011 | SM Caen | - | Montpellier HSC | 2:0 |
France