| 1. Round | 16/07/2021 | Sepsi OSK | - | Academica Clinceni | 2:0 | ||||
| 2. Round | 24/07/2021 | Academica Clinceni | - | CFR Cluj | 1:2 | ||||
| 5. Round | 13/08/2021 | FC Voluntari | - | Academica Clinceni | 1:0 | ||||
| 8. Round | 13/09/2021 | Farul Constanța | - | Academica Clinceni | 5:0 | ||||
| 9. Round | 19/09/2021 | Academica Clinceni | - | Argeș Pitești | 0:1 | ||||
| 10. Round | 25/09/2021 | FCSB | - | Academica Clinceni | 3:2 |  |
|||
| 11. Round | 04/10/2021 | Academica Clinceni | - | FC Botoşani | 1:1 | ||||
| 12. Round | 18/10/2021 | CS Universitatea Craiova | - | Academica Clinceni | 5:0 | |
|||
| 13. Round | 25/10/2021 | Academica Clinceni | - | UTA Arad | 0:3 | ||||
| 14. Round | 31/10/2021 | Gaz Metan Mediaş | - | Academica Clinceni | 1:1 | ||||
| 15. Round | 08/11/2021 | Academica Clinceni | - | Rapid Bucureşti | 2:3 | |
|||
| 16. Round | 19/11/2021 | Academica Clinceni | - | Sepsi OSK | 0:2 | ||||
| 19. Round | 10/12/2021 | FC Universitatea Craiova | - | Academica Clinceni | 1:2 | ||||
| 24. Round | 06/02/2022 | Argeș Pitești | - | Academica Clinceni | 1:0 | ||||
| 25. Round | 09/02/2022 | Academica Clinceni | - | FCSB | 0:3 | |
France