| 1. Round | 07/08/2021 | RC Lens B | - | FC Fleury 91 | 1:3 | ||||
| 3. Round | 21/08/2021 | RC Lens B | - | FC Metz B | 0:2 | ||||
| 4. Round | 28/08/2021 | SC Schiltigheim | - | RC Lens B | 1:0 | ||||
| 5. Round | 04/09/2021 | RC Lens B | - | Entente SSG | 1:0 | ||||
| 6. Round | 11/09/2021 | SAS Épinal | - | RC Lens B | 4:0 | ||||
| 7. Round | 18/09/2021 | RC Lens B | - | ASM Belfort | 1:1 | ||||
| 23. Round | 26/03/2022 | Stade de Reims B | - | RC Lens B | 0:3 | ||||
| 24. Round | 09/04/2022 | RC Lens B | - | AJ Auxerre B | 0:1 | ||||
| 29. Round | 21/05/2022 | RC Lens B | - | AS Beauvais | 2:2 |
France