| 1. Round | 07/08/2021 | US Colomiers | - | Le Puy Foot 43 | 0:1 | ||||
| 2. Round | 14/08/2021 | Angers SCO B | - | US Colomiers | 0:0 | ||||
| 3. Round | 21/08/2021 | US Colomiers | - | Vendée Les Herbiers | 2:2 |  |
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| 6. Round | 11/09/2021 | Andrézieux-Bouthéon FC | - | US Colomiers | 0:1 | ||||
| 7. Round | 18/09/2021 | US Colomiers | - | Bergerac Périgord FC | 0:1 | ||||
| 8. Round | 25/09/2021 | US Colomiers | - | FC Nantes B | 0:2 |  |
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| 9. Round | 09/10/2021 | Canet Roussillon | - | US Colomiers | 1:0 | ||||
| 11. Round | 06/11/2021 | Trélissac FC | - | US Colomiers | 0:0 | ||||
| 12. Round | 20/11/2021 | US Colomiers | - | Moulins Yzeure Foot | 0:1 | |
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| 13. Round | 04/12/2021 | AS Béziers | - | US Colomiers | 3:0 | |
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| 14. Round | 18/12/2021 | US Colomiers | - | Stade Montois | 1:1 | ||||
| 15. Round | 15/01/2022 | Bourges Foot 18 | - | US Colomiers | 4:1 | ||||
| 16. Round | 22/01/2022 | US Colomiers | - | Angers SCO B | 0:0 | |
France